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ATYPICAL PARKINSONISM

MSA-P

HYPOINTENSITY (SWI)

PUTAMEN LATERAL AND POSTERIOR PART

ATROPHY

PUTAMEN: SEEN IN BOTH MSA-C AND MSA-P

FLATTENING OF LATERAL PUTAMEN BORDER

HYPERINTENSITY (FLAIR/ T2)

LATERAL PUTAMEN BORDER

PSP

MORNING GLORY:

MIDBRAIN TEGMENTUM ATROPHY

HYPERINTENSITY:

PONTINE TEGMENTUM

MIBDRAIN TECTUM

PSP VS MSA

MID BRAIN/ PONS DIAMETER RATIO

PSP <0.52 

MSA >0.66

 

MIB BRAIN/ PONS AREA RATIO

NORMAL >0.24

PSP <0.22

MSA >0.29

 

MIB BRAIN AREA

PSP <107 

PONS AREA

MSA <475 

 

NPH VS PSP

NPH CRITERIA:

MRHI <=0.58

MRHI = RATIO OF MAX COLLATERAL TRIGONES OF LATERAL VENTRICLES TO MAX INNER SKULL DIAMETER

SENSITIVITY 93% SPECIFICITY 100%

 

CALLOSAL ANGLE <= 84

SENSITIVITY 86% SPECIFICITY 91%

MRPI INDEX =  (P / M) x (MCP / SCP)

PSP

>12.6/13.55

MSA-C

<7.32 

CORPUS CALLOSUM AREA

CBS

CORPUS CALLOSUM AREA <470

MIDBRAIN ATROPHY

PGRN

C9ORF72

TDP43

GAUCHER DISEASE

PERRY SYNDROME

POLG1 MUTATIONS

SYNJ1 MUTATIONS

MESIAL TEMPORAL HYPERINTENSITY

QUADRIGEMINAL PLATE ATROPHY

WHITE MATTER HYPERINTENSITIES

FIG4 (CMT4J) MUTATIONS

CEREBELLAR ATROPHY

PONS HYPERINTENSITY

MILD  CEREBRAL HYPOMYELINATION

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