ATYPICAL PARKINSONISM
MSA-P
HYPOINTENSITY (SWI)
PUTAMEN LATERAL AND POSTERIOR PART
ATROPHY
PUTAMEN: SEEN IN BOTH MSA-C AND MSA-P
FLATTENING OF LATERAL PUTAMEN BORDER
HYPERINTENSITY (FLAIR/ T2)
LATERAL PUTAMEN BORDER
PSP
MORNING GLORY:
MIDBRAIN TEGMENTUM ATROPHY
HYPERINTENSITY:
PONTINE TEGMENTUM
MIBDRAIN TECTUM
PSP VS MSA
MID BRAIN/ PONS DIAMETER RATIO
PSP <0.52
MSA >0.66
MIB BRAIN/ PONS AREA RATIO
NORMAL >0.24
PSP <0.22
MSA >0.29
MIB BRAIN AREA
PSP <107
PONS AREA
MSA <475
NPH VS PSP
NPH CRITERIA:
MRHI <=0.58
MRHI = RATIO OF MAX COLLATERAL TRIGONES OF LATERAL VENTRICLES TO MAX INNER SKULL DIAMETER
SENSITIVITY 93% SPECIFICITY 100%
CALLOSAL ANGLE <= 84
SENSITIVITY 86% SPECIFICITY 91%
MRPI INDEX = (P / M) x (MCP / SCP)
PSP
>12.6/13.55
MSA-C
<7.32
CORPUS CALLOSUM AREA
CBS
CORPUS CALLOSUM AREA <470
MIDBRAIN ATROPHY
PGRN
C9ORF72
TDP43
GAUCHER DISEASE
PERRY SYNDROME
POLG1 MUTATIONS
SYNJ1 MUTATIONS
MESIAL TEMPORAL HYPERINTENSITY
QUADRIGEMINAL PLATE ATROPHY
WHITE MATTER HYPERINTENSITIES
FIG4 (CMT4J) MUTATIONS
CEREBELLAR ATROPHY
PONS HYPERINTENSITY
MILD CEREBRAL HYPOMYELINATION